Ibuprofen Biological Activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. Ibuprofen inhibits the enzyme cyclooxygenase COX-1 and COX-2, which convert arachidonic acid to prostaglandin H2 (PGH2). Its action is similar to aspirin, indomethacin and all other NSAIDs in intact Ibuprofen. Celebrex is a COX-2-specific NSAID that has a lower propensity for gastrointestinal side effects than many other NSAIDs; however, it still may increase the risk of serious cardiovascular thrombotic more. Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. Ibuprofen was the safest NSAID, conferring a significant 12% increased risk of incident eGFR less than 60, 32% increased risk of an eGFR decline of 30% or greater, and 34% increased risk of the Ibuprofen 800mg Description. Ibuprofen Tablets, USP contain the active ingredient ibuprofen, which is (±)-2-(p-isobutylphenyl) propionic acid.Ibuprofen is a white powder with a melting point of 74° to 77°C and is very slightly soluble in water (<1 mg/mL) and readily soluble in organic solvents such as ethanol and acetone. Pill with imprint 122 is White, Capsule/Oblong and has been identified as Ibuprofen 600 mg. It is supplied by Marksans Pharma Inc. Ibuprofen is used in the treatment of Back Pain; Chronic Myofascial Pain; Aseptic Necrosis; Costochondritis; Juvenile Rheumatoid Arthritis and belongs to the drug class Nonsteroidal anti-inflammatory drugs. prior to Further information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Drug Identifier results for "ibuprofen". Search by imprint, shape, color or drug name. Aspirin or ibuprofen may also cause allergic reactions, with symptoms such as hives, rash, blisters, facial swelling, and wheezing. Taking them together increases this risk as well. Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. The risk of stomach-related side effects is about half that seen with aspirin although the more. Tylenol is an effective mild pain reliever with a low risk of side effects but the potential for liver damage exists, even at recommended Motrin ® IB Ibuprofen Tablets USP, 200 mg. Pain Reliever / Fever Reducer (NSAID) Actual Size. 100 Coated Caplets** **Capsule-Shaped Tablets. INGREDIENTS AND APPEARANCE. Overdosage with ibuprofen may cause nausea, vomiting, epigastric pain, and tinnitus, but more serious toxicity is very uncommon. Charcoal, activated followed by symptomatic measures are indicated if more than 100 mg/kg has been ingested within the preceding hour. For details on the management of poisoning, see Emergency treatment of poisoning. em1T.